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In SAMP mice, which naturally exhibit accelerated aging and genome instability, Epitalon treatment stabilized chromatin structure, supporting a preventative mechanism rooted in epigenetic control and DNA repair [61] One of the most compelling cancer prevention models is the HER-2/neu transgenic mouse, engineered to spontaneously develop mammary tumors

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A phylogenetically tree showed that GpoA present a higher homology with genes found in bacteria that belong to the Phylum Bacillota (before known as Firmicutes ), mainly in the genus Streptococcus (Fig S1)