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However, the LC 50 value of MSNs-ss-SA was determined to be 1.98 mM, approximately six times greater than that of free SA ( LC 50 = 0.336 mM), indicating a significant reduction in toxicity due to the grafting of SA molecules onto MSNs-ss-NH 2

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In DNCB-induced AD mouse model, EGCG-NPs were associated with increased activity of antioxidant enzymes such as SOD and GSH, decreased MDA levels, and enhanced total antioxidant capacity (T-AOC), collectively contributing to the restoration of epidermal redox balance (Han et al., 2022)

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Furthermore, the nutrient mixture rescued unloading-induced mitochondrial defects, by increasing total anti-oxidative capability, mitochondrial copy number and electron transport chain complex I and II activities and markers of mitochondrial biogenesis, such as PGC1, nuclear respiratory factor 1 (NRF1), and mitochondrial transcription factor A (Tfam)

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