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In light of the negative trials with many glutamate-targeted agents, criticisms have arisen indicating that complementary or alternative pathways may be responsible for the antidepressant effects of NMDA-targeted agents [108]

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Finally, the panel posited that as IL-23 inhibitors may be able to limit establishment of IL-17/IL-22 memory cells responsible for relapses in psoriasis, trials are needed focussing on early stage treatment