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5A-5Bshow progression from ototoxicity to systemic toxicity/mortality is a function of the number of cisplatin cycles

A systematic review of 17 clinical studies involving over 25,000 subjects showed that increased systemic TMAO concentrations were correlated with higher cardiovascular events, and the relative risk of all-cause mortality was shown to increase by 7.6% per 10 mol/L increments of plasma TMAO concentration (Schiattarella et al., 2017)

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However, its important to note that each persons response can vary

It is important to distinguish between medication-related effects and those attributable to underlying conditions, lifestyle factors, or psychological responses to body composition changes