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For example, a notable study found that after drinking caffeinated coffee, fat oxidation (fat burning) increased by 29 percent in women with a healthy BMI (body mass index) and by 10 percent in those with obesity

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Importantly, this relationship is bidirectional: progressive MASLD and MASH impair circadian regulation through hyperammonemia, astrocyte dysfunction, altered glutamatergic signaling within the SCN, neuroinflammation, endocrine dysregulation, and HE, thereby reinforcing sleepwake fragmentation and chronobiologic instability