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The convergence of GLP-1 signaling with pathways of aginginsulin sensitivity, mitochondrial function, neuroinflammationsuggests these drugs may influence healthspan, not just body weight. (de Cabo & Mattson, 2019) For women entering their 50s and 60s, this convergence is especially powerful

Excessive caloric intake increases FFA load to the liver to a point that the ability of the hepatocytes to oxidize FFA or re-esterify to TG and secrete very low-density lipoproteins (VLDL) is overwhelmed

Weeks 16 through 24 and beyond: maintenance phase If the combination has been well-tolerated through the titration phase, maintenance involves continuing both compounds at their established doses while reducing bloodwork frequency to monthly

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For example, it has been demonstrated (Brenner et al., 2010) that patients who had TBI with a PTSD comorbidity reported more symptoms than patients who had TBI without PTSD or patients who had PTSD without a history of TBI or concussion