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A ketogenic diet may not be safe for people with chronic constipation, kidney stones, kidney disease, diabetes, heart disease, liver disease, thyroid disorders, or health conditions involving digestive organs such as the pancreas or gallbladder

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It was specifically designed to replicate ghrelin-associated growth hormone signaling while maintaining a narrow receptor interaction profile (11)

The resulting intracellular cholesterol buildup triggers mitochondrial dysfunctionevidenced by diminished ATP synthesis, elevated ROS, and compromised mitochondrial membrane potentialwhich collectively activate HSCs and promote fibrogenesis (104)

Hara KY, Shimodate N, Ito M, Baba T, Mori H, Mori H