is retatrutide a glp-1 drug (not yet approved in US but people using anyway) promises even potentially greater weight loss amongst the GLP1 drugs. https://www.nejm.org/doi/full/10.1056/NEJMoa2301972 Retatrutide - Wikipedia

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However, both have large degrees of Tau and amyloid pathologies which are considered the key players in the pathogenesis of AD (Hampel et al., 2021)