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Though generally mild in children and adults, rubella poses devastating consequences in pregnancy, leading to congenital rubella syndrome (CRS), characterized by cataracts, deafness, cardiac anomalies, and neurologic impairment

This interaction results in either reduced efficacy or increased toxicity of the medications

One publication also suggested that the potential metabolic benefits of berberine could make it a valuable supplement for women who are in the midst of the perimenopausal and postmenopausal transition

And what I started

Studies treating mild to moderate B12 deficiency in older people have failed to provide cognitive benefits: A clinical trial from the Netherlands measured the cognitive response to B12 supplements in people 70 years old with mild B12 deficiency and MMA levels 320 nmol/l (average: ~450 nmol/l)