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The authors also thank Home for researchers editorial team for English language polishing of the manuscript

Starting with tirzepatide injection and optionally adding genetic testing ensures evidence-based, individualized therapy rather than off-label polypharmacy

These genetic differences explain why some people are hyperresponders who feel appetite suppression from the very first dose, while others require several weeks of dose escalation before noticing meaningful changes

Cagrilintide alone: -11.5% REDEFINE 2 (obesity + T2D): Phase 3, 68 weeks, ~1,200 patients