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Whether tirzepatide can enhance adipocyte function such that it may be a mechanism of some of the improvements in lipid profiles as shown in clinical studies requires additional investigation

Dual incretin agonists achieve greater weight reduction than GLP-1RAs alone, and tirzepatide has now demonstrated cardiovascular safety noninferior to a proven GLP-1RA in patients with ASCVD as well as benefit in obesity-related HFpEF [40, 45]