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Compound 2 was inactive as a GLP-1R agonist in the unpotentiated cAMP screening assay (SA), which did not include BETP, but demonstrated a 70% effect at 20 M in the presence of BETP (Fig

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The combination of SGLT2is and GLP-1 RAs was better than GLP-1 RAs in reducing triglycerides and fasting plasma glucose