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Nat Rev Endocrinol 11 , 352362 (2015)

Interestingly, infants with congenital GH deficiency and GHR mutations present with only minor growth retardation, whereas the rare patient with IGF-I deficiency, secondary to a homozygous partial deletion of the IGF-I gene, presents with severe pre and postnatal growth failure, mental retardation, sensorineural deafness, and microcephaly (76-78)

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[DOI] [PubMed] [Google Scholar] 62.Anderson E.I., Spector A