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Doctors who prescribe this combination typically start both drugs at the lowest effective dose

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5 WARNINGS AND PRECAUTIONS 5.1 Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with glucagon-like peptide-1 (GLP-1) receptor agonists, including BYETTA [see Adverse Reactions (6.2)]