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In patients with T2DM, extended treatment with insulin can significantly improve endothelial-dependent vasodilation (113)

However, as patients lose weight, its important to focus on maintaining muscle mass and metabolic health

Before and After: Findings by Outcome Area Across the research literature, IGF-1 LR3s documented effects cluster into four consistent outcome areas: muscle tissue development, fat metabolism, tissue repair, and connective tissue or skin-related processes

,,IparN,AydogduSD,YildirimGK,InalM,GiesIVandenplasYet al.Effects of synbiotic on anthropometry, lipid profile and oxidative stress in obese children.2015;6:775782 66

While most are approved only for diabetes, specific agents in this class have received FDA approval for chronic weight management