Severe IR presents with marked hyperglycaemia despite high insulin doses, sometimes preceded by postprandial hypoglycaemia before beta-cell failure [198]
So while we arent comparing apples to apples when comparing GLP-1 stimulated via diet versus a GLP-1 from medication, we also know that not everyone can take a GLP-1 medication
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Without adequate glutathione to neutralize ROS, superoxide radicals collide with and damage the mitochondria's inner membrane (specifically a lipid called cardiolipin) and the mitochondrial DNA itself
It is usually safe when taken in the recommended dosage under medical guidance
