The Journal of Nutrition, 129(9), 1656-1661
Moreover, the fatsoluble vitamin influences the human microbiota by retaining intestinal homeostasis accomplished due to an increased cellular production of antimicrobial proteins from, for example macrophages and monocytes through RXR/VDR-signaling induction of promotor sequences of cathelicidin antimicrobial peptide etc., thereby preventing intestinal bacterial translocation and, on a large scale, the development of auto-inflammatory / metabolic dysfunctions, along with its role in maintaining intestinal epithelial cell integrity (production of nitric oxide due to upregulation of endothelial nitric oxide synthase (eNOS)), which in turn minimizes epithelial damage caused by bacterial lipopolysaccharides (LPS) [151, 162,163,164,165,166,167,168]
Because myo-inositol acts as an insulin mimeticmeaning it mimics the action of insulin at the cellular levelit can effectively bypass the viral-induced insulin resistance that plagues many patients with chronic post-viral syndromes
This is a state-of-the-art review regarding the role of MMPs in OA and RA, as well as the possible methods of targeting MMPs to alleviate the degradation processes taking part in OA and RA
Important: Every timeline below is extrapolated from animal studies and anecdotal community reports
