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V.GrangeL.SoldiniA.et al (2015)

To understand dosing, we first need to define what this molecule actually does

Diabetologia (2007) 50(1):14250

The Nature Medicine substudy from the 48 week obesity trial assessed mean relative change in liver fat at 24 weeks in participants with metabolic dysfunction associated steatotic liver disease and elevated baseline liver fat, showing how the programme is being explored beyond weight alone using imaging based metrics

The subsequent phase 3 trial of tirzepatide demonstrated more effective reductions in the glycated hemoglobin levels and body weight, along with greater overall improvements in the lipid profile compared to semaglutide in patients with T2DM, elevating incretin therapeutic agents to a new level (112)