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However, another study also in guinea pigs demonstrated that pentoxifylline reduced both cochlear damage and threshold shifts to values similar to untreated animals (Kansu et al., 2016)

However, some of the widely used affinity tags, such as the His-tag, exhibit several drawbacks and limitations, since they can increase the risk of distorting the natural conformation of the target protein or necessitate stringent elution and wash conditions affecting the yield of the target protein

Multi-target combination: The combination of EGFR/VEGF dual-targeting inhibitors showed a synergistic effect in the KRAS mutation model (combination index CI = 0.32) (Yao et al., 2022)

It creates a range of toxins and chemicals that causes harm to the host tissues adhering to successful colonization