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This technology enables extended pharmacological activity through the site-specific conjugation of a cysteine-albuminconjugated Exendin-4 analog (CA-Exendin-4) to the Fc fragment of human immunoglobulin G subclass 4 (IgG4), linked via a flexible peptide spacer (Fig

If additional blood sugar control is needed, the dose can then be increased in 2.5 mg steps

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GLP-1 agonists mitigate this process through direct actions on vascular and immune cells, in addition to their systemic metabolic effects