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One study found that glutathione supplementation helped protect against oxidative stressinduced cell death by supporting mitochondrial function and activating the bodys own defense system, which boosts antioxidant activity

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Cell-sorted studies have revealed widespread methylation shifts in T cells and monocytes, including reproducible changes in CD8+ T cells and distinct profiles relative to CD4+ subsets, indicative of compartment-specific immune methylome remodeling (138-141)

Many of these pathways require adequate NAD+ levels for optimal function, meaning NAD+ restoration before treatment could be a strategy to ensure the underlying cells are in an optimal condition to respond to the treatment