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Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle-Aged Adults

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Switching at higher body weights Patients with a BMI above 40 or body weight above 300 pounds may respond differently to the standard titration protocol

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However, the FDA approval of Aducanumab is controversial, with the ultimate basis of approval predicated on apparent reduction of A plaques and not inhibition of clinical disease outcome (Rabinovici, 2021)