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GLP-1 also acts as a satiety signal by activating receptors on vagal afferent neurons that transmit signals from the gut to the hypothalamic satiety centers, including regions that regulate appetite, energy expenditure, and food reward

They share the same fasting requirements but differ in dose and indication

Because GLP1R expression is lower in cells than in and cells, the direct effects of GLP1 on cells are relatively limited

Adverse Gastrointestinal Effects of GLP-1 Receptor Agonists . National Library of Medicine

GLP-1 semaglutide medication mimics the GLP-1 hormone that is known to increase feelings of fullness and slows gastric emptying, further increasing the feeling of fullness