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Glutamate can be further converted to -ketoglutarate (-KG) through oxidative deamination by glutamate dehydrogenase (GLUD1) or transamination by glutamate-linked transaminase as an anaplerotic substrate in the TCA cycle for energy production (Figure 1)

It protects brain mitochondria from oxidative stress and recycles other antioxidants, such as vitamins C and E

doi: 10.3389/fncel.2022.889765, 20 ChenK

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This research deepens our understanding of NRF2s role in cellular homeostasis and lays the foundation for the development of NRF2-targeted therapies