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However, more research is needed to confirm these claims

Crucially, ApoER2 signaling in the brain is responsible for both early stage neuronal development and also adult synaptogenesis and learning in the Reelin pathway that is primarily activated through ApoE binding to ApoER2, for which ApoER2 is heavily expressed in the hippocampus and neocortex, in particular in granule cells and pyramidal cells (Fernndez-Calle et al., 2022)

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Directions Warnings For external use only Do not use on damaged or broken skin When using this product keep out of eyes

The FDA-approved dose of 1.75 mg was chosen partly to balance efficacy against the nausea rate seen at higher doses in early trials