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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

Collagen fiber maturity scores at 14 days post-treatment in BPC-157 groups match untreated tendon scores at 21 to 28 days, indicating a compressed healing timeline

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The -subunit of hCG has a highly glycosylated 24-amino acid C-terminal tail absent from LH, which increases receptor activity and slows metabolic clearance resulting in a half-life of approximately 36 hours for hCG compared to just 30 minutes for LH, making hCG an extended-duration pharmacological analogue of LH for receptor biology research