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Future investigations should implement standardized exercise prescriptions, longer follow-up, and preregistered multicenter designs to ensure methodological consistency and improve translational relevance

Clinicians should consider the following factors: Diagnosis of type 2 diabetes, confirmed without autoimmune markers Failure to achieve glycemic control with lifestyle changes and metformin Obesity (BMI 95th percentile for age and sex) A supportive family environment and readiness to adhere to treatment Early discussions about the role of GLP1 therapy help align expectations and clarify both risks and benefits

Regular follow-up appointments allow for monitoring of both therapeutic response and side effects

This is a promising and innovative route toward the development of unimolecular peptide drugs with superior efficacy than those currently available for the treatment of obesity and T2DM

Furthermore, information on GLP-1 receptor expression in the heart is still lacking, and whether GLP-1RAs act directly or indirectly on the cardiovascular system remains inconclusive