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GLP-1 Medications: What the Evidence Shows Clinical trials of semaglutide and tirzepatidetwo leading GLP-1 receptor agonistsshow weight loss of 10 to 22 percent over 68 weeks, with significant improvements in blood sugar control and cardiovascular markers

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Ozempic and Zepbound are both effective weight loss medications, as they contain semaglutide, a GLP-1 receptor agonist