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The earliest reproducible patient-reported change is often improved sleep, sometimes within the first few weeks

Storage in a cool, dry place away from direct sunlight and heat to maintain the stability and integrity of peptides

Gut health The high level of the amino acid glutamine in collagen has been shown to help heal the gut lining and may help reduce gut inflammation and leaky gut problems that contribute to autoimmunity and symptoms in patients with hypothyroidism

Vaginal smear was daily obtained as described previously 42 and only those showing at least two consecutive normal vaginal estrus cycles (45 days) were used in the experiments