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Slow dose escalation is the primary strategy The most effective way to minimize heart rate effects is slow, gradual dose escalation

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Additionally, GSTM1 is a negative regulator of ASK1, a kinase involved in the apoptotic pathway [49]

The control group (non-AIHD group), included 39 cases with no clinical history or macroscopic and microscopic findings of cardiac pathology from various causes of deaths described in Table 1