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Aug 14 2020;10(8)doi:10.3390/biom10081181

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[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses

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Guideline 4: Laboratory Monitoring and Dose Adjustments Laboratory monitoring is key in checking how well B12 treatment works

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Generally, the clinical measurement of BAs is of total BAs, which represent over 20 BAs in most species (Luo et al

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