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We replaced the complex equations of enzyme-mediated fluxes of the reduced model (Figure 2A) with simple mass action kinetics in the stylized model (Figure 2B)

Looking forward, the integration of TCM with contemporary biomedical technologies holds great promise for the treatment of PF

Levels of 2,3-BPG may be elevated up to two times normal in PK-deficient individuals, resulting in decreased hemoglobin oxygen affinity

Alternatively, the bound-form glutathione may be degraded into amino acids on the cell membrane surface and the resulting amino acids may be incorporated into the hepatocytes and then used for intracellular glutathione synthesis

Gupta, V