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It increases fibroblast migration and dispersal, induces F-actin formation in fibroblasts, modulates angiogenesis, and enhances vascular expression of VEGFR2

Fat tissue, especially the visceral fat around the abdomen, is full of an enzyme called aromatase that converts testosterone into estrogen

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DOI Portillo Canales S, et al

Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once daily Route of Administration : Subcutaneous injection Dosing Frequency : Once daily Half-Life : ~38 minutes in HIV+ patients 2 Formulation : Lyophilized acetate salt for reconstitution Formulation & Handling Reconstitute lyophilized powder in sterile bacteriostatic water for injection (0.9% benzyl alcohol) Store reconstituted solution at 28C and use within 14 days Unreconstituted vials should be stored at 20C in a dry, light-protected environment Avoid repeated freeze-thaw cycles