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These nuclear receptors act as transcription factors rather than membrane receptors

In the hinge-latch hypothesis, the conformation of the Nrf2Keap1 complex is altered upon oxidative stress, implying that induction of target genes is only facilitated by newly synthesized Nrf2

In contrast to the liver, the lung is composed of many different cell types and expression of GSTs in different human lung cell types is heterogenous

On the flip side, CJC 1295 extends the duration of growth hormone secretion by mimicking the action of growth hormone-releasing hormone (GHRH), thus prolonging its effects