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At each stenosis, we simulated 4 situations: no catheter/pressure wire insertion (in vivo status), catheter inserted proximally to ICAS without pressure wire, catheter inserted and pressure sensor placed at 1cm&2cm distally to ICAS lesion

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The CRF 2 shows a wide distribution in the brain, most notably in the amygdala, lateral septum, supraoptic nucleus, ventromedial hypothalamus, dorsal raphe nuclei, area postrema, the nucleus of the solitary tract and the spinal cord (Bittencourt and Sawchenko, 2007

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Every major trial to date including SURPASS-4 and SUMMIT shows the opposite: steadier filtration rates, lower protein leakage, and no sign of renal toxicity