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The published literature investigates Melanotan 2 as a non-selective agonist at melanocortin receptors (MC1R, MC3R and MC4R) in pre-clinical and in-vitro model systems

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More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1." This switch around was so unexpected, the researchers ran further tests on mouse models with the PAM gene deactivated