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doi: 10.1007/s00401-003-0688-z 261
For some, diet and exercise may not be enough to see substantial results, particularly when factors like insulin resistance, slow metabolism, or hormonal imbalances are at play
Approved in 1964 for the management of hypertension, propranolol is now used for a wide range of cardiovascular diseases, including ischemic heart disease, angina pectoris, arrhythmias, and myocardial infarction, as well as non cardiovascular conditions, including migraine, tremors and anxiety
HDAC inhibitors (HDACi) remodel lipid metabolism by upregulating key enzymes such as acyl-CoA synthetase long-chain family member 4 (ACSL4) and P450 oxidoreductase (POR), while downregulating solute carrier family 7 member 11 (SLC7A11), which triggers lipid peroxidation accumulation and ultimately induces ferroptosis, thus inhibiting GC progression [108]
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