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Importantly, this pathway is enzymatically tractable, as the enzymes that control CoQ 10 reduction are druggable oxidoreductases, making the CoQ 10 axis a promising pharmacological entry point for ferroptosis-based cancer therapy

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Fonseca VA, Devries JH, Henry RR, Donsmark M, Thomsen HF, Plutzky J

However, when a high glucose drink was supplemented to mice lacking gut microbiota, there was no significant difference in the survival between mice groups

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