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Neuropathy and Nerve Damage in Diabetes Diabetic neuropathy, a common and debilitating complication of diabetes, stems largely from hyperglycemia-induced oxidative stress, which increases reactive oxygen species production and damages peripheral nerves [42]

Diabetes 122 , 528532 (2014)

Diabetes increases platelet responsiveness to subthreshold stimuli, encouraging thrombotic events and the generation of new hyperreactive platelets (176)

Each sample mixed with light (endogenous) and heavy (synthetic) peptides was quantified by integrating the quantifier fragment ions to derive a light-to-heavy peptide ratio

As hypothesized, we found the level of total GSH, free GSH, and GSSG to be significantly reduced in the EDTA-treated plasma stored at 4 o C compared to the non-deproteinized EDTA-treated plasma stored at 80 o C (Preparation Condition 3)