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10.1016/S0168-9452(01)00485-X 96 LiY.DankherO

Obese mice and rats treated with AOD9604 showed significant decreases in adipose tissue depot weights, reductions in adipocyte size observed histologically, and improvements in body composition measured by DEXA scanning or MRI

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Contrave is not appropriate for people with seizure disorders, uncontrolled high blood pressure, certain eating disorder histories, or current opioid use

Structured trials speed discovery: change one variable for 3 to 5 days and log meals, dosing, and symptoms, since a 4-week symptom-log analysis showed isolating variables rapidly uncovers repeatable triggers