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It is clear that the CNS is necessary for GLP-1R mediated induction of visceral illness as mice with a CNS deletion of the GLP-1R develop conditioned taste aversion (CTA) to lithium chloride but not to liraglutide (Sisley et al., 2014)

The authors concluded that, in this large real-world cohort of nondiabetic women with elevated BMI and no prior breast cancer, GLP-1 RA exposure was associated with both a modest reduction in incident HR-positive/HER2-negative breast cancer and meaningfully improved OS

J Clinic Investigat

In fact, they were named as the 2023 Breakthrough of the Year by Science.org

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