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Relationship between amyloid- deposition and bloodbrain barrier dysfunction in Alzheimers disease

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Positron emission tomography (PET) has demonstrated that substantially decreased levels of dopamine D2 receptors in alcohol and drug dependent subjects are relative to those levels in non-dependent individuals [32]

Therefore, the sponsors concluded that clinically significant DDIs mediated by direct inhibition of CYP enzymes or transporters are unlikely to occur with the administration of GLP-1 RAs and a dual GLP-1/GIP RA