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118,119 Furthermore, SIRT1 negatively regulates the NLRP3 inflammasome, suppressing pyroptosis and protecting hepatocytes from excessive immune-mediated damage

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Mutations in the KISS1 gene or disorders of the kisspeptin/KISS1R system may lead to clinical symptoms such as idiopathic hypogonadotropic hypogonadism (iHH), central precocious puberty (CPP) and female infertility