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Conclusion GLP-1 receptor agonists like Ozempic and Mounjaro are highly effective in managing obesity and type 2 diabetes, but their side effects can sometimes be challenging

Levels of glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione reductase (GR), malondialdehyde (MDA), reduced glutathione (GSH), and catalase (CAT) were measured

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The most promising compounds, 39 and 40 (Figure 6), showed an IC 50 of 2.80 nM against DPP-4 catalytic activity, with 20 - 40-fold selectivity over the DPP-8 and DPP-9 isozymes