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The healthy acid mantle maintains a surface pH of approximately 4.5 to 5.5, which regulates enzyme activity, supports barrier lipid processing, and inhibits pathogenic microbial colonization

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

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32 Behavioral assessments confirmed the development of PTSD-like symptoms, with mice exhibiting impaired fear extinction and retrieval in the contextual fear conditioning (CFC), as indicated by increased freezing behavior during retrieval sessions compared to controls (Fig