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The FDA-approved labels for GLP-1 receptor agonists acknowledge effects on satiety but emphasize their primary metabolic actions

In HFD-induced rat models of insulin resistance and hepatic steatosis, FBA showed comparable therapeutic efficacy to NaBu, with significantly greater potency in reducing pro-inflammatory parameters, lipid accumulation, and HMGB1 transcription [103]

Endoscopic procedures, particularly endoscopic sleeve gastroplasty, offer a favorable safety profile and are an alternative for patients who do not want to undergo metabolic-bariatric surgery, though they currently lack insurance coverage in the United States

Researchers at the Weizmann Institute of Science, who have been tabulating national data, said a sharp decline in hospitalization and serious illness identified earlier among people aged 60 or more, was being seen for the first time in those aged 55 and older

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