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discovered that the CAF-derived exosome LINC01614 can activate the NF-B signaling pathway by interacting with ANXA2 and p65 (58)

doi: 10.1152/ajpregu.00634.2009 33

Collectively, these findings broaden the implication of biomaterial-based tolerance strategies by confirming that nanoparticles can effectively deliver diverse CNS autoantigens, including PLP, MBP, and AQP4, to re-establish antigen-specific immune regulation across multiple mechanistically distinct autoimmune diseases

Nevertheless, in the past few years, seven randomized phase III clinical trials, which tested other first-line and second-line treatments, in intermediate-stage or advanced-stage HCC patients have not found any obvious OS benefits (Llovet et al., 2015)

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