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The SUSTAIN 7 trial showed average reductions of 1.8% at the 1.0 mg dose compared to 1.4% with dulaglutide at its highest dose

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Semaglutide activates GLP-1 receptors in the brain and gut, which slows the rate at which food moves from the stomach into the small intestine

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N Engl J Med 2019;381:84151.PubMed 37