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The overlap explains that the effects talked about online are not just pigmentation

Annals of Clinical and Laboratory Science (2015) 6

Novel compounds and therapeutic approaches exhibit restricted clinical efficacy attributable to factors such as short half-life, in vivo stability, and challenges associated with blood-brain barrier penetration, among others (177)

But with that comes great need for respect of the process

The marketing around GLP-1 boosting supplements has moved much faster than the science, and many consumers now assume these products offer effects comparable to prescription GLP-1 receptor agonists which simply isnt the case