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From baseline until 1 week after the last dose of randomised treatment, a total of 13 participants (3.8%) in the IcoSema group and 71 participants (20.8%) in the semaglutide group initiated non-randomised insulin or additional non-insulin glucose-lowering medications for more than 2 weeks, with most of them initiating oral glucose-lowering medications rather than insulin treatment

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It functions as a GLP-1 receptor agonist, targeting brain areas responsible for appetite control , thereby helping to decrease hunger and reduce calorie intake

doi:10.4103/aja.aja_42_19

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